Effects Of Pregnancy On Patients With A History Of...

Original Quantitative Research Question: Does use of progesterone in early pregnancy explain viable pregnancies in patients with a history of miscarriage? Change One: In pregnant patients with a history of miscarriage, how does progesterone use compared to no treatment affect the viability of a pregnancy within nine months? Change Two: In a random sample of pregnant women with a history of recurrent miscarriage of unknown etiology, how does the application of 400 mg of progesterone, vaginally, twice daily for the first twelve weeks of pregnancy compared to no treatment affect the viability of a pregnancy within 26 weeks of gestation? P - Population: A random sample of pregnant women with a history of recurrent miscarriage with unknown etiology I - Intervention: Application of 400 mg of progesterone, vaginally, twice daily for the first 12 weeks gestation C – Comparison: No treatment O – Outcome: Viable pregnancy at 26 weeks gestation T – Time: Seven months Article One Palagiano, A., Bulletti, C., Pace, M. C., de Ziegler, D., Cicinelli, E., Izzo, A. (2004). Effects of vaginal progesterone on pain and uterine contractility in patients with threated abortion before twelve weeks of pregnancy. Annals of the New York Academy of Sciences, 1034, 200-210. doi:10.1196/annals.1335.022 This study evaluated the effects of supplemental progesterone use on pain and uterine contractions in early pregnancy. 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